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Acetyl coenzyme A (trilithium)
SKU
HY-114293A-Get quote
Category Biochemical Assay Reagents
Tags Autophagy;Endogenous Metabolite, Autophagy;Metabolic Enzyme/Protease, Metabolic Disease; Cardiovascular Disease
Products Details
Product Description
– Acetyl-coenzyme A (Acetyl-CoA) trilithium is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A trilithium regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A trilithium is also a key precursor of lipid synthesis[1][2][3][4].
Web ID
– HY-114293A
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C23H35Li3N7O17P3S
References
– [1]Choudhary C, et al. The growing landscape of lysine acetylation links metabolism and cell signalling. Nat Rev Mol Cell Biol. 2014 Aug;15(8):536-50.|[2]Mariño G, et al. Regulation of autophagy by cytosolic acetyl-coenzyme A. Mol Cell. 2014 Mar 6;53(5):710-25.|[3]Zhu H, et al. Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest. 2007 Jul;117(7):1782-93.|[4]Pietrocola F, et al. Acetyl coenzyme A: a central metabolite and second messenger. Cell Metab. 2015 Jun 2;21(6):805-21.
CAS Number
– 75520-41-1
Molecular Weight
– 827.37
SMILES
– O[C@H]1[C@@H](O[C@H](COP(OP(OCC(C)([C@H](O)C(NCCC(NCCSC(C)=O)=O)=O)C)(O[Li])=O)(O[Li])=O)[C@H]1OP(O)(O[Li])=O)N2C3=C(C(N)=NC=N3)N=C2
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease; Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Autophagy;Endogenous Metabolite
Pathway
– Autophagy;Metabolic Enzyme/Protease
Product type
– Biochemical Assay Reagents
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