Products Details

Product Description

– Acetyl-coenzyme A (Acetyl-CoA) trilithium is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A trilithium regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A trilithium is also a key precursor of lipid synthesis[1][2][3][4].

Web ID

– HY-114293A

Shipping

– Room temperature

Applications

– COVID-19-immunoregulation

Molecular Formula

– C23H35Li3N7O17P3S

References

– [1]Choudhary C, et al. The growing landscape of lysine acetylation links metabolism and cell signalling. Nat Rev Mol Cell Biol. 2014 Aug;15(8):536-50.|[2]Mariño G, et al. Regulation of autophagy by cytosolic acetyl-coenzyme A. Mol Cell. 2014 Mar 6;53(5):710-25.|[3]Zhu H, et al. Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest. 2007 Jul;117(7):1782-93.|[4]Pietrocola F, et al. Acetyl coenzyme A: a central metabolite and second messenger. Cell Metab. 2015 Jun 2;21(6):805-21.

CAS Number

– 75520-41-1

Molecular Weight

– 827.37

SMILES

– O[C@H]1[C@@H](O[C@H](COP(OP(OCC(C)([C@H](O)C(NCCC(NCCSC(C)=O)=O)=O)C)(O[Li])=O)(O[Li])=O)[C@H]1OP(O)(O[Li])=O)N2C3=C(C(N)=NC=N3)N=C2

Clinical Information

– No Development Reported

Research Area

– Metabolic Disease; Cardiovascular Disease

Solubility

– 10 mM in DMSO

Target

– Autophagy;Endogenous Metabolite

Pathway

– Autophagy;Metabolic Enzyme/Protease

Product type

– Biochemical Assay Reagents

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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