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Products Details
Product Description
– Acetaminophen-13C2,15N is the 13C and 15N labeled Acetaminophen[1]. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM;is a widely used antipyretic and analgesic agent[2][3][4]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[5].
Web ID
– HY-66005S4
Shipping
– Room temperature
Molecular Formula
– C6 13C2H9 15NO2
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Hinz, B, et al. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J, 2008. 22(2): p. 383-90.|[3]Miroslav Dinić, et al. Lactobacillus fermentum Postbiotic-induced Autophagy as Potential Approach for Treatment ofAcetaminophen Hepatotoxicity. Front Microbiol. 2017 Apr 68:594.|[4]Uchida NS, et al. Hepatoprotective Effect of Citral on Acetaminophen-Induced Liver Toxicity in Mice. Evid Based Complement Alternat Med. 20172017:1796209.|[5]Rothen JP, et al. Acetaminophen is an inhibitor of hepatic N-acetyltransferase 2 in vitro and in vivo. Pharmacogenetics. 1998 Dec8(6):553-9.
CAS Number
– 360769-21-7
Molecular Weight
– 154.14
SMILES
– [13CH3][13C]([15NH]C1=CC=C(C=C1)O)=O
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Bacterial;COX;Endogenous Metabolite;Histone Acetyltransferase;Parasite
Pathway
– Anti-infection;Epigenetics;Immunology/Inflammation;Metabolic Enzyme/Protease
Product type
– Isotope-Labeled Compounds
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