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AC-4-130
$250 – $2,250
Products Details
Product Description
– AC-4-130 is a potent STAT5 SH2 domain inhibitor. AC-4-130 directly binds to STAT5 and disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription. AC-4-130 induces cell cycle arrest and apoptosis in FLT3-ITD-driven leukemic cells. AC-4-130 has anti-cancer activity and can efficiently block pathological levels of STAT5 activity in acute myeloid leukemia (AML)[1].
Web ID
– HY-124500
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C37H36ClF5N2O5S
References
– [1]Bettina Wingelhofer, et al. Pharmacologic inhibition of STAT5 in acute myeloid leukemia. Leukemia. 2018 May;32(5):1135-1146.
CAS Number
– 1834571-82-2
Molecular Weight
– 751.20
Compound Purity
– 99.87
SMILES
– FC1=C(C(F)=C(C(F)=C1F)S(=O)(N(CC2=CC=C(C=C2)Cl)CC(N(C3=CC=C(C=C3)C(O)=O)CC4=CC(C(C)(C)C)=CC(C(C)(C)C)=C4)=O)=O)F
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 100 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL (ultrasonic)
Target
– Apoptosis;STAT
Isoform
– STAT5
Pathway
– Apoptosis;JAK/STAT Signaling;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
