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Products Details
Product Description
– ABT-724 is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM). ABT-724 has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 could be useful for the treatment of erectile dysfunction and has favorable side-effect profile[1].
Web ID
– HY-14330
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C17H19N5
References
– [1] Brioni JD, et al. Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6758-63.
CAS Number
– 70006-24-5
Molecular Weight
– 293.37
SMILES
– C1(NC(CN2CCN(C3=NC=CC=C3)CC2)=N4)=C4C=CC=C1
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Dopamine Receptor
Isoform
– D4 Receptor;D5 Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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