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ABT-384

SKU HY-111262-10 mg Category Reference compound Tags 11β-HSD, Metabolic Disease; Neurological Disease, Metabolic Enzyme/Protease

$350 – $2,600

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Products Details

Product Description

– ABT-384 is a potent, selective 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor. ABT-384 exhibits high affinity (Ki 0.1-2.7 nM) against rodent, monkey, and human 11β-HSD1. ABT-384 blocks regeneration of active cortisol. ABT-384 can be used for the research of Alzheimer’s disease (AD)[1][2].

Web ID

– HY-111262

Storage Temperature

– 4°C (Powder, protect from light)

Shipping

– Room Temperature

Applications

– Metabolism-sugar/lipid metabolism

Molecular Formula

– C25H34F3N5O2

References

– [1]Katz DA, et al. Peripheral and central nervous system inhibition of 11β-hydroxysteroid dehydrogenase type 1 in man by the novel inhibitor ABT-384. Transl Psychiatry. 2013;3(8):e295. Published 2013 Aug 27.|[2]Liu W, et al. Clinical Safety, Pharmacokinetics, and Pharmacodynamics of the 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor ABT-384 in Healthy Volunteers and Elderly Adults. Clin Pharmacol Drug Dev. 2013;2(2):133-151.

CAS Number

– 868623-40-9

Molecular Weight

– 493.56

Compound Purity

– 99.94

SMILES

– NC([C@]12C[C@@H](C3)C(NC(C(C)(N4CCN(C5=CC=C(C(F)(F)F)C=N5)CC4)C)=O)[C@@H](C[C@@H]3C2)C1)=O

Clinical Information

– Phase 2

Research Area

– Metabolic Disease; Neurological Disease

Solubility

– DMSO : 31.25 mg/mL (ultrasonic;warming;heat to 60°C)

Target

– 11β-HSD

Pathway

– Metabolic Enzyme/Protease

Product type

– Reference compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.