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Abemaciclib metabolite M2
$150 – $1,350
Products Details
Product Description
– Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s of 1.2 and 1.3 nM, respectively. Anti-cancer activity[1][2].
Web ID
– HY-128669
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C25H28F2N8
References
– [1]CHMP. Assessment report Verzenios. 26 July 2018 EMA/551438/2018.|[2]Teresa Burke, et al. Abstract 2830: The major human metabolites of abemaciclib are inhibitors of CDK4 and CDK6. Cancer Research. July 2016, 76 (14).
CAS Number
– 1231930-57-6
Molecular Weight
– 478.54
Compound Purity
– 99.94
SMILES
– CC(N1C2=CC(C3=NC(NC4=NC=C(CN5CCNCC5)C=C4)=NC=C3F)=CC(F)=C2N=C1C)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 2 mg/mL (ultrasonic)
Target
– CDK;Drug Metabolite
Isoform
– CDK4;CDK6
Pathway
– Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
