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Abemaciclib metabolite M2-d6
$1,750
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Products Details
Product Description
– Abemaciclib metabolite M2-d6 is the deuterium labeled Abemaciclib metabolite M2. Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s in the range of 1-3 nM. Anti-cancer activity[1][2].
Web ID
– HY-128669S
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture and light)
Shipping
– Blue Ice
Applications
– Cancer-Kinase/protease
Molecular Formula
– C25H22D6F2N8
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Teresa Burke, et al. Abstract 2830: The major human metabolites of abemaciclib are inhibitors of CDK4 and CDK6. Cancer Research. July 2016, 76 (14).
Molecular Weight
– 484.58
Compound Purity
– 99.25
SMILES
– CC1=NC2=C(C=C(C3=C(C=NC(NC4=CC=C(C=N4)CN5CCNCC5)=N3)F)C=C2N1C(C([2H])([2H])[2H])C([2H])([2H])[2H])F
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 2.12 mg/mL (ultrasonic)
Target
– CDK
Pathway
– Cell Cycle/DNA Damage
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
