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Products Details
Product Description
– ABCG2-IN-1 (compound K2), a Ko143 analog, is an orally active ABCG2 inhibitor with an IC50 of 0.13 μM. ABCG2-IN-1 has favorable oral pharmacokinetic profiles in mice[1].
Web ID
– HY-155652
Shipping
– Room temperature
Molecular Formula
– C26H36N4O4
References
– [1]Junjie Zhu, et al. Metabolism-guided development of Ko143 analogs as ABCG2 inhibitors. Eur J Med Chem. 2023 Nov 5;259:115666.
CAS Number
– 2559759-40-7
Molecular Weight
– 468.59
SMILES
– CC(C)C[C@H]1C2=C(C[C@]3([H])N1C([C@@H](NC3=O)CCC(NC(C)(C)C)=O)=O)C4=CC=C(OC)C=C4N2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– BCRP
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
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