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Products Details
Product Description
– A3AR antagonist 2 (compound 18) is a potent Human A3 adenosine receptor antagonist with an Ki value of 4.54 nM[1].
Web ID
– HY-12099
Shipping
– Room temperature
Molecular Formula
– C22H16N6O3
References
– [1]Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a New Scaffold To Develop Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation, and Ligand?Receptor Modeling Studies
J. Med. Chem., 2009, 52 (8), pp 2407-2419|[2]Vittoria Colotta, et al. Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a New Scaffold To Develop Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation, and Ligand−Receptor Modeling Studies. J. Med. Chem. 2009, 52, 8, 2407-2419.
CAS Number
– 1144161-05-6
Molecular Weight
– 412.40
SMILES
– O=C(NC1=NC2=NC=CC=C2N3C1=NN(C4=CC=C(OC)C=C4)C3=O)C5=CC=CC=C5
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Adenosine Receptor
Isoform
– Adenosine A3 receptor (A3R)
Pathway
– GPCR/G Protein
Product type
– Reference compound
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