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Products Details
Product Description
– A3AR antagonist 1 (compound 17) is a potent and selective human A3 adenosine receptor (AR) antagonist, with an Ki of 4.63 nM. A3AR antagonist 1 shows no affinity for the rat A3 AR even at high concentrations[1].
Web ID
– HY-146457
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C32H24N4O4S
References
– [1]Abdelrahman A, et, al. Substituted 4-phenylthiazoles: Development of potent and selective A 1, A 3 and dual A 1/A 3 adenosine receptor antagonists. Eur J Med Chem. 2020 Jan 15;186:111879.
CAS Number
– 2413257-74-4
Molecular Weight
– 560.62
SMILES
– COC1=CC=C(C=C1)C(NC2=NC(C3=CC=CC=C3)=C(S2)C4=NC5=C(C(N4C6=CC=C(C=C6)OC)=O)C=CC=C5)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Adenosine Receptor
Isoform
– Adenosine A3 receptor (A3R)
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
