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Products Details
Product Description
– A-987306 is a potent and oral bioavailable histamine H4 antagonist, with Kis of 3.4 nM and 5.8 nM for rat H4, and human H4. A-987306 shows anti-inflammatory activity in mice peritonitis model[1].
Web ID
– HY-14364
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C18H25N5O
References
– [1]cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), A New Histamine H4R Antagonist that Blocks Pain Responses against Carrageenan-Induced Hyperalgesia
J. Med. Chem., 2008, 51 (22), pp 7094-7098
CAS Number
– 1082954-71-9
Molecular Weight
– 327.42
SMILES
– NC1=NC(N2CCNCC2)=C3CCC(O[C@]4([H])[C@@]5([H])CCCC4)=C5C3=N1
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Histamine Receptor
Pathway
– GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling
Product type
– Reference compound
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