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Products Details
Product Description
– A-9758 is a RORγ ligand and a potent, selective RORγt inverse agonist (IC50=5 nM), and exhibits robust potency against IL-17A release. A-9758 is effective in suppressing both Th17 differentiation and Th17 effector function. A-9758 significantly attenuates IL-23 driven psoriasiform dermatitis and is effective in blocking skin and joint inflammation[1].
Web ID
– HY-126252
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C25H23Cl2F3N2O3
References
– [1]Gauld S, et al. Inhibition of IL-23 mediated inflammation with a novel small molecule inverse agonist of RORgt. J Pharmacol Exp Ther. 2019 Aug 2. pii: jpet.119.258046.
CAS Number
– 2055271-22-0
Molecular Weight
– 527.36
SMILES
– O=C(C1CCN(C(C2=CC=C(Cl)C(CC(N3C)=CC4=C3C=C(C(F)(F)F)C=C4C)=C2Cl)=O)CC1)O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Interleukin Related;ROR
Isoform
– IL-17;IL-23;RORγ
Pathway
– Immunology/Inflammation;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
