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Products Details
Product Description
– A-893 is a cell-active inhibitor of Methyltransferase SMYD2, with an IC50 of 2.8 nM.
Web ID
– HY-19563
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C29H38Cl2N4O4
References
– [1]Sweis RF, et al. Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2. ACS Med Chem Lett. 2015 Apr 29;6(6):695-700.
CAS Number
– 1868232-32-9
Molecular Weight
– 577.54
SMILES
– O=C(CCNCCC1=CC(Cl)=C(Cl)C=C1)N(C2CCCCC2)CCNC[C@H](O)C3=CC=CC(N4)=C3OCC4=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Histone Methyltransferase
Isoform
– SMYD2
Pathway
– Epigenetics
Product type
– Reference compound
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