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A 83-01
$40 – $500
Products Details
Product Description
– A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I nodal receptor ALK4 and type I nodal receptor ALK7, with IC50s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7, respectively[1].
Web ID
– HY-10432
Storage Temperature
– -20°C (Powder, protect from light, stored under nitrogen)
Shipping
– Blue Ice
Applications
– Cancer-Kinase/protease
Molecular Formula
– C25H19N5S
Citations
– Adv Sci (Weinh). 2022 Sep;9(26):e2202505.|Am J Physiol Cell Physiol. 2023 May 1.|Cell Prolif. 2022 Aug 3;e13320.|Cell Rep. 2022 Jul 12;40(2):111053.|Cell Rep. 2023 May 23;42(6):112546.|Cell Stem Cell. 2022 Sep 1;29(9):1346-1365.e10.|FASEB J. 2020 Aug;34(8):11185-11199.|FASEB J. 2023 Dec;37(12):e23279.|FASEB J. 2023 Jul;37(7):e22983.|Front Med. 2021 Sep 23;8:746298.|Gynecol Oncol. 2019 Jun;153(3):639-650.|Int J Radiat Oncol Biol Phys. 2023 Oct 9:S0360-3016(23)07970-1.|J Pharm Anal. 2023 Sep 22.|J Transl Med. 2021 Dec 7;19(1):497.|Methods Mol Biol. 2021 Jun 15.|Methods Mol Biol. 2022 Dec 15.|Methods Mol Biol. 2023 Jun 24.|Mol Oncol. 2023 Oct 23.|Nano Res. 03 August 2022.|Nat Cell Biol. 2022 Jun;24(6):858-871.|Nat Commun. 2022 Sep 6;13(1):5237.|Nat Protoc. 2023 Feb 15.|Patent. US20220389379A1.|Research Square Preprint. 2021 Jan.|Sci Adv. 2021 Apr 14;7(16):eabb2213.|Theranostics. 2021 Mar 14;11(11):5539-5552.|J Biol Chem. 2022 Aug 12;102374.|Science. 2020 Dec 4;370(6521):eaay2002.
References
– [1]Tojo M, et al. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. Cancer Sci. 2005 Nov;96(11):791-800.|[2]Yamamura S, et al. The activated transforming growth factor-beta signaling pathway in peritoneal metastases is a potential therapeutic target in ovarian cancer. Int J Cancer. 2012 Jan 1;130(1):20-8.|[3]Taniguchi Y, et al. Enhanced antitumor efficacy of folate-linked liposomal Adriamycin with TGF-β type I receptor inhibitor. Cancer Sci. 2010 Oct;101(10):2207-13.
CAS Number
– 909910-43-6
Molecular Weight
– 421.52
Compound Purity
– 99.08
SMILES
– S=C(N1N=C(C2=NC(C)=CC=C2)C(C3=CC=NC4=CC=CC=C34)=C1)NC5=CC=CC=C5
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : ≥ mg/mL
Target
– TGF-β Receptor
Isoform
– ALK4;ALK5;ALK7
Pathway
– TGF-beta/Smad
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
