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8-Hydroxyefavirenz
SKU
HY-137397-Get quote
Category Reference compound
Tags Apoptosis;JNK, Apoptosis;MAPK/ERK Pathway, Cancer
Products Details
Product Description
– 8-Hydroxyefavirenz (8-OH-EFV) is a primary metabolite of (HY-10572). 8-Hydroxyefavirenz induces apoptosis via a JNK- and BimEL-dependent mechanism in primary human hepatocytes. 8-Hydroxyefavirenz can be used in research of cancer[1]. 8-Hydroxyefavirenz is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Web ID
– HY-137397
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C14H9ClF3NO3
References
– [1]Bumpus NN. Efavirenz and 8-hydroxyefavirenz induce cell death via a JNK- and BimEL-dependent mechanism in primary human hepatocytes. Toxicol Appl Pharmacol. 2011 Dec 1;257(2):227-34.
CAS Number
– 205754-33-2
Molecular Weight
– 331.67
SMILES
– O=C1NC2=C(O)C=C(Cl)C=C2[C@](C(F)(F)F)(C#CC3CC3)O1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;JNK
Pathway
– Apoptosis;MAPK/ERK Pathway
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.