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Products Details
Product Description
– 7DG (7-Desacetoxy-6,7-dehydrogedunin) is a protein kinase R (PKR) inhibitor. 7DG protects macrophages from lethal toxin-induced pyroptosis[1].
Web ID
– HY-124857
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C26H30O5
References
– [1]Hett EC, et, al. Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis. Nat Chem Biol. 2013 Jun;9(6):398-405. |[2]Chukwurah E, et, al. A tale of two proteins: PACT and PKR and their roles in inflammation. FEBS J. 2021 Nov;288(22):6365-6391.
CAS Number
– 26927-01-5
Molecular Weight
– 422.51
SMILES
– O=C1O[C@@H](C2=COC=C2)[C@]3(C)CC[C@@]4([H])[C@](C=C[C@@]5([H])C(C)(C)C(C=C[C@@]54C)=O)(C)[C@@]36[C@@H]1O6
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– PERK
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
