7DG

SKU HY-124857-Get quote Category Tags , ,

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Products Details

Product Description

– 7DG (7-Desacetoxy-6,7-dehydrogedunin) is a protein kinase R (PKR) inhibitor. 7DG protects macrophages from lethal toxin-induced pyroptosis[1].

Web ID

– HY-124857

Shipping

– Room temperature

Applications

– COVID-19-anti-virus

Molecular Formula

– C26H30O5

References

– [1]Hett EC, et, al. Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis. Nat Chem Biol. 2013 Jun;9(6):398-405. |[2]Chukwurah E, et, al. A tale of two proteins: PACT and PKR and their roles in inflammation. FEBS J. 2021 Nov;288(22):6365-6391.

CAS Number

– 26927-01-5

Molecular Weight

– 422.51

SMILES

– O=C1O[C@@H](C2=COC=C2)[C@]3(C)CC[C@@]4([H])[C@](C=C[C@@]5([H])C(C)(C)C(C=C[C@@]54C)=O)(C)[C@@]36[C@@H]1O6

Clinical Information

– No Development Reported

Research Area

– Inflammation/Immunology

Solubility

– 10 mM in DMSO

Target

– PERK

Pathway

– Cell Cycle/DNA Damage

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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