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Products Details
Product Description
– 7,8-Didehydrocimigenol is an active triterpenoid that can be isolated from Cimicifugae rhizoma. 7,8-Didehydrocimigenol inhibits TNF-α-induced VCAM-1 expression, inhibits NF-kB activity and phosphorylation of ERK1/2 and Akt, increases PPAR-γ expression. 7,8-Didehydrocimigenol can be used for the research of cardiovascular disorders such as atherosclerosis[1].
Web ID
– HY-N10047
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C30H46O5
References
– [1]Mun L, et al. 7,8-didehydrocimigenol from Cimicifugae rhizoma inhibits TNF-α-induced VCAM-1 but not ICAM-1expression through upregulation of PPAR-γ in human endothelial cells. Food Chem Toxicol. 2011 Jan;49(1):166-72.
CAS Number
– 150972-72-8
Molecular Weight
– 486.68
SMILES
– C[C@]12C3=CC[C@](C(C)([C@H](CC4)O)C)([H])[C@]54[C@@]3(CC[C@@]1([C@]6([H])[C@@]7(O[C@@H]([C@H](O7)C(C)(O)C)C[C@H]6C)[C@@H]2O)C)C5
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– NF-κB;PPAR
Pathway
– Cell Cycle/DNA Damage;NF-κB;Vitamin D Related/Nuclear Receptor
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
