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Product Description
– 7-Hydroxyneolamellarin A is a natural product that could be derived from sponge Dendrilla nigra. 7-Hydroxyneolamellarin A is a potent hypoxia-inducible factor-1α (HIF-1α) inhibitor. 7-Hydroxyneolamellarin A attenuates the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibits vascular epidermal growth factor (VEGF) transcriptional activity. 7-Hydroxyneolamellarin A can be used in research of cancer[1].
Web ID
– HY-N10330
Shipping
– Room temperature
Molecular Formula
– C24H19NO5
References
– [1]Li G, et, al. Total synthesis and biological evaluation of 7-hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy. Bioorg Med Chem Lett. 2021 Oct 15;50:128338.
CAS Number
– 959662-26-1
Molecular Weight
– 401.41
SMILES
– OC1=CC=C(C(O)C(N2C=C(C3=CC=C(O)C=C3)C(C4=CC=C(O)C=C4)=C2)=O)C=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– HIF/HIF Prolyl-Hydroxylase;VEGFR
Pathway
– Metabolic Enzyme/Protease;Protein Tyrosine Kinase/RTK
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
