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7α,25-Dihydroxycholesterol-d6
Products Details
Product Description
– 7α,25-Dihydroxycholesterol-d6 is deuterium labeled 7α,25-Dihydroxycholesterol. 7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly
Web ID
– HY-113962S
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C27H40D6O3
References
– [1]Hannedouche S, et al. Oxysterols direct immune cell migration via EBI2. Nature. 2011 Jul 27;475(7357):524-7.|[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.|[3]Liu C, et al. Oxysterols direct B-cell migration through EBI2. Nature. 2011 Jul 27;475(7357):519-23.
CAS Number
– 2260669-11-0
Molecular Weight
– 424.69
SMILES
– C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C([2H])([2H])[2H])(O)C([2H])([2H])[2H])([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C[C@H](CC4)O)=C[C@H]3O)C
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– EBI2/GPR183;Endogenous Metabolite;Isotope-Labeled Compounds
Pathway
– GPCR/G Protein;Metabolic Enzyme/Protease;Others
Product type
– Isotope-Labeled Compounds
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