Download Files:
653-47 (hydrochloride)
$250 – $1,950
Products Details
Product Description
– 653-47 hydrochloride, a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. 653-47 hydrochloride is also a very weak CREB inhibitor with IC50 of 26.3 μM[1].
Web ID
– HY-134598A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C20H20Cl2N2O3
References
– [1]Xie F, et al. Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666-15. J Med Chem. 2019;62(24):11423-11429.
CAS Number
– 1224567-46-7
Molecular Weight
– 407.29
Compound Purity
– 99.42
SMILES
– O=C(C1=C(OCCCN)C=C2C=CC=CC2=C1)NC3=CC=C(Cl)C=C3O.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 250 mg/mL (ultrasonic)
Target
– Epigenetic Reader Domain
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
