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Products Details
Product Description
– 6′-GNTI dihydrochloride, a κ-opioid receptor (KOR) agonist, displays bias toward the activation of G protein-mediated signaling over β-arrestin2 recruitment. 6′-GNTI 6′-GNTI dihydrochloride only activates the Akt pathway in striatal neurons[1].
Web ID
– HY-110302
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C27H31Cl2N5O3
References
– [1]Schmid CL, et al. Functional selectivity of 6′-guanidinonaltrindole (6′-GNTI) at κ-opioid receptors in striatal neurons. J Biol Chem. 2013;288(31):22387-22398.
CAS Number
– 2410327-94-3
Molecular Weight
– 544.47
SMILES
– O[C@]12[C@](C3=C(C=C4)C[C@H]2N5CC6CC6)(CC5)[C@](OC3=C4O)([H])C(NC7=CC(NC(N)=N)=CC=C87)=C8C1.Cl.Cl
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Opioid Receptor
Isoform
– κ Opioid Receptor/KOR
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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