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5′-Methylthioadenosine-d3
$220
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Products Details
Product Description
– 5′-Methylthioadenosine-d3 is the deuterium labeled 5′-Methylthioadenosine[1]. 5′-Methylthioadenosine (5′-(Methylthio)-5′-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis. 5′-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5′-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis[2][3][4].
Web ID
– HY-16938S1
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C11H12D3N5O3S
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Tang Y, et al. 5′-Methylthioadenosine attenuates ischemia reperfusion injury after liver transplantation in rats. Inflammation. 2014;37(5):1366-1373.2018;78(15):4386-4395.|[3]Li Y, et al. 5′-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019;10(4):927-936.|[4]Tang B, et al. Specific Targeting of MTAP-Deleted Tumors with a Combination of 2′-Fluoroadenine and 5′-Methylthioadenosine. Cancer Res.|[5]Yaofeng Li, et al. 5′-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019;10(4):927-936.
CAS Number
– 174838-38-1
Molecular Weight
– 300.35
Compound Purity
– 99.81
SMILES
– NC1=C2N([C@]3([H])O[C@@H]([C@H]([C@H]3O)O)CSC([2H])([2H])[2H])C=NC2=NC=N1
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Endogenous Metabolite;Parasite
Pathway
– Anti-infection;Apoptosis;Metabolic Enzyme/Protease
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
