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Products Details
Product Description
– 5-HT6R antagonist 1 (Comopund 8) is a 5-HT6R antagonist (Ki: 5 nM). 5-HT6R antagonist 1 inhibits platelet aggregation. 5-HT6R antagonist 1 has excellent metabolic stability. 5-HT6R antagonist 1 reverses MK-801 (HY-15084B)-induced memory impairments in rats. 5-HT6R antagonist 1 can be used for Alzheimer’s disease (AD) research[1].
Web ID
– HY-156017
Shipping
– Room temperature
Molecular Formula
– C17H22F2N6O
References
– [1]Sudoł-Tałaj S, et al. Hydrophobicity modulation via the substituents at positions 2 and 4 of 1,3,5-triazine to enhance therapeutic ability against Alzheimer’s disease for potent serotonin 5-HT6R agents. Eur J Med Chem. 2023 Nov 15;260:115756.
Molecular Weight
– 364.39
SMILES
– NC1=NC(C(OC2=CC(F)=CC=C2F)CC)=NC(N3CCN(C)CC3)=N1
Clinical Information
– No Development Reported
Research Area
– Neurological Disease; Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– 5-HT Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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