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Products Details
Product Description
– 5-HT6R antagonist 1 (Comopund 8) is a 5-HT6R antagonist (Ki: 5 nM). 5-HT6R antagonist 1 inhibits platelet aggregation. 5-HT6R antagonist 1 has excellent metabolic stability. 5-HT6R antagonist 1 reverses MK-801 (HY-15084B)-induced memory impairments in rats. 5-HT6R antagonist 1 can be used for Alzheimer’s disease (AD) research[1].
Web ID
– HY-156017
Shipping
– Room temperature
Molecular Formula
– C17H22F2N6O
References
– [1]Sudoł-Tałaj S, et al. Hydrophobicity modulation via the substituents at positions 2 and 4 of 1,3,5-triazine to enhance therapeutic ability against Alzheimer’s disease for potent serotonin 5-HT6R agents. Eur J Med Chem. 2023 Nov 15;260:115756.
Molecular Weight
– 364.39
SMILES
– NC1=NC(C(OC2=CC(F)=CC=C2F)CC)=NC(N3CCN(C)CC3)=N1
Clinical Information
– No Development Reported
Research Area
– Neurological Disease; Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– 5-HT Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
