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Products Details
Product Description
– 5-HT6/5-HT2A receptor ligand-2 (compound 42) is a brain-penetrant dual 5-HT6/5-HT2A receptor antagonist, with a Ki of 25 nM and 32 nM, respectively. 5-HT6/5-HT2A receptor ligand-2 shows pro-cognitive properties[1].
Web ID
– HY-146077
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C20H18FN3O2
References
– [1]Staroń J, et, al. Virtual screening-driven discovery of dual 5-HT 6/5-HT 2A receptor ligands with pro-cognitive properties. Eur J Med Chem. 2020 Jan 1;185:111857.
CAS Number
– 2411088-16-7
Molecular Weight
– 351.37
SMILES
– OC1=CC=C(C2=CC=C(CNCCC3=CNC4=NC=C(F)C=C43)O2)C=C1
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– 5-HT Receptor
Isoform
– 5-HT2 Receptor;5-HT6 Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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