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Product Description
– 5-Aminosalicylic Acid-d3 (hydrochloride) is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) hydrochloride acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.
Web ID
– HY-15027S
Shipping
– Room temperature
Molecular Formula
– C7H5D3ClNO3
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Dammann K, et al. PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation. Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2349-60.;Fang HM, et al. 5-aminosalicylic acid in combination with Nimesulide inhibits proliferation of colon carcinoma cells in vitro. World J Gastroenterol. 2007 May 28;13(20):2872-7.;Rousseaux C, et al. The 5-aminosalicylic acid antineoplastic effect in the intestine is mediated by PPARγ. Carcinogenesis. 2013 Nov;34(11):2580-6.
CAS Number
– 1346601-18-0
Molecular Weight
– 192.61
SMILES
– OC(C1=C(C([2H])=C([2H])C(N)=C1[2H])O)=O.Cl
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Cancer
Solubility
– 10 mM in DMSO
Target
– Endogenous Metabolite;Isotope-Labeled Compounds;NF-κB;PAK;PPAR
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton;Metabolic Enzyme/Protease;NF-κB;Others;Vitamin D Related/Nuclear Receptor
Product type
– Isotope-Labeled Compounds
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