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Product Description
– 5-Aminosalicylic acid-13C6 is the 13C labeled 5-Aminosalicylic Acid[1]. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[2][3][4].
Web ID
– HY-15027S2
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C 13C6H7NO3
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Dammann K, et al. PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation. Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2349-60.|[3]Fang HM, et al. 5-aminosalicylic acid in combination with Nimesulide inhibits proliferation of colon carcinoma cells in vitro. World J Gastroenterol. 2007 May 2813(20):2872-7.|[4]Rousseaux C, et al. The 5-aminosalicylic acid antineoplastic effect in the intestine is mediated by PPARγ. Carcinogenesis. 2013 Nov34(11):2580-6.
CAS Number
– 1189709-96-3
Molecular Weight
– 159.09
SMILES
– OC([13C]1=[13C]([13CH]=[13CH][13C](N)=[13CH]1)O)=O
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Endogenous Metabolite;NF-κB;PAK;PPAR
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton;Metabolic Enzyme/Protease;NF-κB;Vitamin D Related/Nuclear Receptor
Product type
– Isotope-Labeled Compounds
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