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Products Details
Product Description
– (4aS,8aR)-NPD-001 is a potent and allosteric inhibitor of DNMT3A. (4aS,8aR)-NPD-001 inhibits DNMT3A activity by disrupting protein-protein interactions. (4aS,8aR)-NPD-001 induces apoptosis of acute myeloid leukemia (AML) cell lines. (4aS,8aR)-NPD-001 induces differentiation of distinct AML cell lines including cells with mutated DNMT3A R882[1].
Web ID
– HY-150025
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C33H40N6O4
References
– [1]Sandoval JE, et al. First-in-Class Allosteric Inhibitors of DNMT3A Disrupt Protein-Protein Interactions and Induce Acute Myeloid Leukemia Cell Differentiation. J Med Chem. 2022 Jul 22.
CAS Number
– 2366272-43-5
Molecular Weight
– 584.71
SMILES
– O=C1N(C2CCCCCC2)N=C(C3=CC=C(OC)C(OCCCCOC4=CC=C(C5=NN=NN5)C=C4)=C3)[C@@]6([H])CC=CC[C@@]16[H]
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;DNA Methyltransferase
Isoform
– DNMT3
Pathway
– Apoptosis;Epigenetics
Product type
– Reference compound
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