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4,5-Dimethoxycanthin-6-one
$450 – $720
Products Details
Product Description
– 4,5-Dimethoxycanthin-6-one is a potent and uncompetitive inhibitor of CYP1A2-mediated phenacetin O-deethylation with an IC50 value of 1.7μM and a Ki value of 2.6 μM. 4,5-Dimethoxycanthin-6-one, as an alkaloid, is isolated from the wood of Picrasma quassioides BENNET (Simaroubaceae)[1][2].
Web ID
– HY-N1882
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C16H12N2O3
References
– [1]Taichi O, et al. Studies on the Constituents of Picrasma quassioides BENNET. III. The Alkaloidal Constituents|[2]Miao X,et al. In vitro metabolism of 4, 5-dimethoxycanthin-6-one by human liver microsomes and its inhibition on human CYP1A2. Life Sci. 2017;190:46-51.
CAS Number
– 18110-87-7
Molecular Weight
– 280.28
Compound Purity
– 98.68
SMILES
– O=C1N2C3=C(N=CC=C3C4=C2C=CC=C4)C(OC)=C1OC
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– DMSO : 10 mg/mL (ultrasonic)
Target
– Cytochrome P450
Isoform
– CYP1
Pathway
– Metabolic Enzyme/Protease
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
