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Products Details
Product Description
– 4-Oxofenretinide (4-Oxo-4-HPR) is a metabolite of Fenretinide (HY-15373). 4-Oxofenretinide induces cell growth inhibition in ovarian, breast, and neuroblastoma tumor cell lines. 4-Oxofenretinide causes a marked accumulation of cells in G2-M. 4-Oxofenretinide induces cancer cell apoptosis through caspase-9[1].
Web ID
– HY-109583
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C26H31NO3
References
– [1]Villani MG, et al. 4-oxo-fenretinide, a recently identified fenretinide metabolite, induces marked G2-M cell cycle arrest and apoptosis in fenretinide-sensitive and fenretinide-resistant cell lines. Cancer Res. 2006 Mar 15;66(6):3238-47.|[2]Villani
MG, et al. 4-oxo-fenretinide, a recently identified fenretinide metabolite,
induces marked G2-M cell cycle arrest and apoptosis in fenretinide-sensitive
and fenretinide-resistant cell lines. Cancer Res. 2006 Mar 15;66(6):3238-47.
CAS Number
– 865536-65-8
Molecular Weight
– 405.53
SMILES
– OC(C=C1)=CC=C1NC(/C=C(C)/C=C/C=C(C)/C=C/C(C(C)(CC2)C)=C(C)C2=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Drug Metabolite;Reactive Oxygen Species
Pathway
– Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Product type
– Reference compound
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