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Products Details
Product Description
– 4-Methoxylonchocarpin is an orally active anti-inflammatory agent. 4-methoxylonchocarpin inhibits the binding of LPS to Toll-like Receptor (TLR) TLR4 to inhibit NF-κB activation and TNF Receptor and IL-6 expression. 4-Methoxylonchocarpin also inhibits the phosphorylation of TGF-beta activated kinase 1 and TNBS-induced expression of IL-1β, IL-17A, and TNF. 4-methoxylonchocarpin can improve 2,4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis mouse model[1].
Web ID
– HY-N11768
Shipping
– Room temperature
Molecular Formula
– C21H20O4
References
– [1]Jang HM, et al. 4-Methoxylonchocarpin attenuates inflammation by inhibiting lipopolysaccharide binding to Toll-like receptor of macrophages and M1 macrophage polarization. Int Immunopharmacol. 2017 Apr;45:90-97.
CAS Number
– 51589-67-4
Molecular Weight
– 336.38
SMILES
– OC1=C2C(OC(C)(C=C2)C)=CC=C1C(/C=C/C3=CC=C(C=C3)OC)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Interleukin Related;NF-κB;Toll-like Receptor (TLR)
Pathway
– Immunology/Inflammation;NF-κB
Product type
– Reference compound
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