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Products Details
Product Description
– 4′-Hydroxytamoxifen is a metabolite of Tamoxifen. 4′-Hydroxytamoxifen shows higher affinity for the ER than Tamoxifen. 4′-Hydroxytamoxifen induces a non-apoptotic cytotoxic effect in human endometrial adenocarcinoma cells[1].
Web ID
– HY-124414
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C26H29NO2
References
– [1]Cuevas ME, et, al. In vitro cytotoxicity of 4′-OH-tamoxifen and estradiol in human endometrial adenocarcinoma cells HEC-1A and HEC-1B. Oncol Rep. 2015 Jan;33(1):464-70.
CAS Number
– 82413-23-8
Molecular Weight
– 387.51
SMILES
– CC/C(C1=CC=C(C=C1)O)=C(C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Drug Metabolite;Estrogen Receptor/ERR
Pathway
– Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
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