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Product Description
– 4′-Hydroxy diclofenac-13C6 is the 13C labeled 4′-Hydroxy diclofenac[1]. 4′-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4′-Hydroxy diclofenac has anti-inflammatory and analgesic properties[2][3].
Web ID
– HY-15550S1
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C8 13C6H11Cl2NO3
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]J Shimamoto, et al. Lack of Differences in Diclofenac (A Substrate for CYP2C9) Pharmacokinetics in Healthy Volunteers With Respect to the Single CYP2C9*3 Allele. Eur J Clin Pharmacol. 2000 Apr;56(1):65-8.|[3]Hidetaka Kamimura, et al. Formation of the Accumulative Human Metabolite and Human-Specific Glutathione Conjugate of Diclofenac in TK-NOG Chimeric Mice With Humanized Livers. Drug Metab Dispos. 2015 Mar43(3):309-16.
CAS Number
– 1189656-64-1
Molecular Weight
– 318.10
SMILES
– ClC(C=C(C=C1Cl)O)=C1N[13C]2=[13C]([13CH]=[13CH][13CH]=[13CH]2)CC(O)=O
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Drug Metabolite
Pathway
– Metabolic Enzyme/Protease
Product type
– Isotope-Labeled Compounds
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