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4-Deoxypyridoxine 5′-phosphate
$120 – $850
Products Details
Product Description
– 4-Deoxypyridoxine 5′-phosphate is a Pyridoxal 5′-phosphate analogue and a sphingosine 1-phosphate (S1P) inhibitor. 4-Deoxypyridoxine 5′-phosphate inhibits ornithine decarboxylase activity with a Ki of 60 μM. 4-Deoxypyridoxine 5′-phosphate is a competitive inhibitor of the activation of glutamate apodecarboxylase by Pyridoxal 5′-phosphate (Ki of 0.27 μM) and strongly inhibits glutamate-dependent labeling of glutamate decarboxylase[1][2][3].
Web ID
– HY-N2553
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C8H12NO5P
References
– [1]Mamoru Ohtoyo, et al. Scintillation Proximity Assay to Detect the Changes in Cellular Dihydrosphingosine 1-Phosphate Levels. Lipids. 2016 Oct;51(10):1207-1216.|[2]M J Connor, et al. Epidermal Pyridoxal 5′-phosphate Depletion, Inhibition of DNA Synthesis, and Inhibition of the Expression of Ornithine Decarboxylase Activity by the Vitamin B-6 Antagonist 4′-deoxypyridoxine. J Invest Dermatol. 1983 Aug;81(2):136-9.|[3]D L Martin, et al. Glutamate-dependent Active-Site Labeling of Brain Glutamate Decarboxylase. J Neurochem. 1990 Aug;55(2):524-32.
CAS Number
– 883-84-1
Molecular Weight
– 233.16
Compound Purity
– 98.0
SMILES
– CC1=C(C(C)=NC=C1COP(O)(O)=O)O
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– LPL Receptor
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
