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Product Description
– 3,3′-Difluorobenzaldazine (DFB) is a selective positive allosteric modulator of mGluR5. 3,3′-Difluorobenzaldazine potentiates 3- to 6-fold action for mGlu5 agonists (Glutamate, Quisqualate, and 3,5-Dihydroxyphenylglycine), with EC50s in the 2 to 5 μM range[1].
Web ID
– HY-14611
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C14H10F2N2
References
– [1]O’Brien JA, et al, Chen TB, et al. A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol Pharmacol. 2003;64(3):731-740.|[2]O’Brien JA, et al. A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol Pharmacol. 2003;64(3):731-740.
CAS Number
– 15332-10-2
Molecular Weight
– 244.24
SMILES
– FC1=CC(/C=N/N=C/C2=CC=CC(F)=C2)=CC=C1
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– mGluR
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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