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3-Hydroxykynurenine
$180 – $280
Products Details
Product Description
– 3-Hydroxykynurenine, a metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronal apoptosis[1].
Web ID
– HY-113294
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture and light)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C10H12N2O4
References
– [1]S Okuda, et al. 3-Hydroxykynurenine, an endogenous oxidative stress generator, causes neuronal cell death with apoptotic features and region selectivity. J Neurochem. 1998 Jan;70(1):299-307.|[2]Sarah S Zaher,et al. 3-hydroxykynurenine suppresses CD4+ T-cell proliferation, induces T-regulatory-cell development, and prolongs corneal allograft survival. Invest Ophthalmol Vis Sci. 2011 Apr 22;52(5):2640-8.
CAS Number
– 484-78-6
Molecular Weight
– 224.21
Compound Purity
– 99.33
SMILES
– O=C(O)C(N)CC(C1=CC=CC(O)=C1N)=O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 1M HCl : 33.33 mg/mL (ultrasonic;adjust pH to 1 with HCl)
Target
– Apoptosis;Endogenous Metabolite
Isoform
– Human Endogenous Metabolite
Pathway
– Apoptosis;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
