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3′-Azido-2′,3′-dideoxyuridine
$85 – $760
Products Details
Product Description
– 3′-Azido-2′,3′-dideoxyuridine (AzdU) is a nucleoside analog of Zidovudine (HY-17413). 3′-Azido-2′,3′-dideoxyuridine is a potent inhibitor of human immunodeficiency virus (HIV) replication in human peripheral blood mononuclear cells (PBMC) with limited toxicity for human bone marrow cells (BMC)[1][2][3]. 3′-Azido-2′,3′-dideoxyuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
Web ID
– HY-106850
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– COVID-19-anti-virus
Molecular Formula
– C9H11N5O4
References
– [1]Zhu Z, et al. Cellular metabolism of 3′-azido-2′,3′-dideoxyuridine with formation of 5′-O-diphosphohexose derivatives by previously unrecognized metabolic pathways for 2′-deoxyuridine analogs. Mol Pharmacol. 1990 Dec;38(6):929-38.|[2]Chu CK, et al. Structure-activity relationships of pyrimidine nucleosides as antiviral agents for human immunodeficiency virus type 1 in peripheral blood mononuclear cells. J Med Chem. 1989 Mar;32(3):612-7.|[3]Kong L, et al. Pharmacokinetic evaluation of 3′-azido-2′, 3′-dideoxyuridine-5′-O-valinate-hydrochloride as a prodrug of the anti-HIV nucleoside 3′-azido-2′, 3′-dideoxyuridine. Antivir Chem Chemother. 2003 Sep;14(5):263-70.
CAS Number
– 84472-85-5
Molecular Weight
– 253.21
Compound Purity
– 99.11
SMILES
– OC[C@H]([C@@H](N=[N+]=[N-])C1)O[C@H]1N(C=C2)C(NC2=O)=O
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– DMSO : 250 mg/mL (ultrasonic)
Target
– HIV
Isoform
– HIV
Pathway
– Anti-infection
Product type
– Reference compound
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