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(2S,3R)-LP99
$566
Only 1000 item(s) left in stock.
Products Details
Product Description
– (2S,3R)-LP99 is a potent and selective BRD7 and BRD9 inhibitor with an KD of 99 nM for BRD9. (2S,3R)-LP99 inhibits the association of BRD7 and BRD9 to acetylated histones in vitro and in cells. (2S,3R)-LP99 demonstrates that BRD7/9 plays a role in regulating pro-inflammatory cytokine secretion[1].
Web ID
– HY-116227
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C26H30ClN3O4S
References
– [1]Clark PG, et al. LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor. Angew Chem Int Ed Engl. 2015 May 18;54(21):6217-21.
CAS Number
– 1808948-28-8
Molecular Weight
– 516.05
SMILES
– CC(CS(=O)(N[C@@H]([C@@H](N1C2=CC3=C(C(C)=CC(N3C)=O)C=C2)C4=CC=C(C=C4)Cl)CCC1=O)=O)C
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Epigenetic Reader Domain
Isoform
– BRD7;BRD9
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
