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2′,5′-Dideoxyadenosine
$95 – $1,350
Products Details
Product Description
– 2′,5′-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site with an IC50 of 3 µM . 2′,5′-Dideoxyadenosine is a nucleoside analog and exerts a potent antiadrenergic action in heart[1][2].
Web ID
– HY-135878
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C10H13N5O2
References
– [1]Bushfield M, et al. Tissue levels, source, and regulation of 3′-AMP: an intracellular inhibitor of adenylyl cyclases. Mol Pharmacol. 1990 Dec;38(6):848-53.|[2]Hartmann M, et al. Isoproterenol antagonistic effect of 2′,5′-dideoxyadenosine in the isolated perfused guinea-pig heart. J Mol Cell Cardiol. 1993 Mar;25(3):331-8.|[3]Zhao LX, et al. M1 muscarinic receptors regulate the phosphorylation of AMPA receptor subunit GluA1 via a signaling pathway linking cAMP-PKA and PI3K-Akt. FASEB J. 2019 May;33(5):6622-6631.|[4]Leme Tdos S, et al. Role of prostaglandin/cAMP pathway in the diuretic and hypotensive effects of purified fraction of Maytenus ilicifolia Mart ex Reissek (Celastraceae). J Ethnopharmacol. 2013 Oct 28;150(1):154-61.
CAS Number
– 6698-26-6
Molecular Weight
– 235.24
Compound Purity
– 99.93
SMILES
– C[C@@H]1[C@H](C[C@H](N2C=NC3=C(N=CN=C32)N)O1)O
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– DMSO : 125 mg/mL (ultrasonic)
Target
– Adenylate Cyclase;Adrenergic Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
