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2′,3′-cGAMP
$300 – $1,250
Products Details
Product Description
– 2′,3′-cGAMP (2′-3′-cyclic GMP-AMP) is a endogenous cGAMP in mammalian cells. 2′,3′-cGAMP binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2′,3′-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm[1].
Web ID
– HY-100564
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C20H24N10O13P2
Citations
– Acta Materia Medica . 2023 Jun 17.|Cell Commun Signal. 2023 Sep 28;21(1):264.|J Immunol. 2021 Apr 15;206(8):1844-1857.|J Virol. 2023 Oct 16:e0127923.|Cell Rep. 2023 Feb 28;42(3):112145.|Fundamental Research. 2023 May 11.|Neuron. 2022 Nov 4;S0896-6273(22)00961-8.|Protein Cell. 2021 Oct 22;1-21.
References
– [1]Zhang X, et al. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol Cell. 2013 Jul 25;51(2):226-35.
CAS Number
– 1441190-66-4
Molecular Weight
– 674.41
Compound Purity
– 99.71
SMILES
– OC1([H])[C@](OP(O)(OC[C@](O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@@H]4O)([H])[C@@]4([H])O5)=O)([H])[C@H](N6C(NC(N)=NC7=O)=C7N=C6)O[C@]1([H])COP5(O)=O
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– H2O : ≥ 50 mg/mL
Target
– Endogenous Metabolite;IFNAR;STING
Pathway
– Immunology/Inflammation;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
