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Products Details
Product Description
– 20S Proteasome-IN-4 (Compound 7) is a brain-penetrant, parasite-selective, orally active 20S proteasome inhibitor with an IC50 of 6.3 nM against T. b. brucei 20S proteasome. 20S Proteasome-IN-4 can be used for the research of human African trypanosomiasis (HAT)[1].
Web ID
– HY-151195
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C20H18ClF2N3O3
References
– [1]Koester DC, et al. Discovery of Novel Quinoline-Based Proteasome Inhibitors for Human African Trypanosomiasis (HAT). J Med Chem. 2022 Aug 22.
CAS Number
– 2827061-47-0
Molecular Weight
– 421.83
SMILES
– ClC1=CC=C2C(C(NC3=CC=CC(F)=C3F)=CC(C(NC[C@H](CO)OC)=O)=N2)=C1
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Parasite;Proteasome
Pathway
– Anti-infection;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
