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Products Details
Product Description
– 20S Proteasome-IN-3 is a 20S proteasome β5 subunit inhibitor (IC50=1.64 μM)[1][2]. 20S Proteasome-IN-3 shows anti-tumor proliferation activity[2].
Web ID
– HY-150591
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C34H43N3O8
References
– [1]Qi Sun, et al. Design and synthesis of tripeptidyl furylketones as selective inhibitors against the β5 subunit of human 20S proteasome. Eur J Med Chem. 2020 Apr 15;192:112160.|[2]Qi Sun, et al. Synthesis, bioactivity, docking and molecular dynamics studies of furan-based peptides as 20S proteasome inhibitors. ChemMedChem. 2015 Mar;10(3):498-510.
CAS Number
– 1803040-07-4
Molecular Weight
– 621.72
SMILES
– OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](CC(C)C)C(C2=CC=CO2)=O)=O)NC([C@@H](NC(OC(C)(C)C)=O)CC3=CC=C(C=C3)OC)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Proteasome
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
