Download Files:
Products Details
Product Description
– 20S Proteasome-IN-2 is a human 20S proteasome inhibitor. 20S Proteasome-IN-2 shows high selectivity to its β5 subunit with the IC50 of 0.18 μM. 20S Proteasome-IN-2 displays anti-proliferative effect in vitro and in vivo, and arrests cell cycle at G2/M[1].
Web ID
– HY-150590
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C30H44N4O8S
References
– [1]Sun Q, et al. Design and synthesis of tripeptidyl furylketones as selective inhibitors against the β5 subunit of human 20S proteasome. Eur J Med Chem. 2020 Apr 15. 192:112160.
CAS Number
– 2028300-31-2
Molecular Weight
– 620.76
SMILES
– O=C(N[C@@H](COC)C(N[C@@H](CC(C)C)C(C1=CC=CO1)=O)=O)[C@@H](NS(=O)(C2=CC=C(C)C=C2)=O)CC(NCC(C)(C)C)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Proteasome
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
