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2′-O,4′-C-Methyleneguanosine
$170 – $280
Products Details
Product Description
– 2′-O,4′-C-Methyleneguanosine (LNA-G) is a reverse guanine analogue, where LNA (locked nucleic acid) is a nucleic acid analogue. LNA modification can be used in a variety of applications such as effective binding affinity to complementary sequences and greater nuclease resistance than natural nucleotides, offering great potential for applications in disease diagnosis and research. LNA-G is also available via KOD DNA polymerase, which allows the integration of LNA-G nucleotides into the DNA strand[1][2].
Web ID
– HY-W406070
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C11H13N5O5
References
– [1]Rakesh N. Veedu, et al. Polymerase directed incorporation studies of LNA-G nucleoside 5′-triphosphate and primer extension involving all four LNAnucleotides. New J. Chem., 2010,34, 877-879|[2]Haase L, et al. Locked nucleic acid building blocks as versatile tools for advanced G-quadruplex design. Nucleic Acids Res. 2020 Oct 9;48(18):10555-10566.
CAS Number
– 207131-16-6
Molecular Weight
– 295.25
Compound Purity
– 98.0
SMILES
– OC[C@]12[C@@H](O)[C@@H](OC2)[C@H](N3C(N=C(N)NC4=O)=C4N=C3)O1
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– 10 mM in DMSO
Target
– DNA/RNA Synthesis, Nucleoside Antimetabolite/Analog
Pathway
– Cell Cycle/DNA Damage
Product type
– Oligonucleotides
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
