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Products Details
Product Description
– 2-Keto Crizotinib (PF-06260182) is an active lactam metabolite of crizotinib.
Web ID
– HY-13320
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C21H20Cl2FN5O2
References
– [1]Balis FM, e al. First-dose and steady-state pharmacokinetics of orally administered crizotinib in children with solid tumors: a report on ADVL0912 from the Children’s Oncology Group Phase 1/Pilot Consortium. Cancer Chemother Pharmacol. 2017 Jan;79(1):181-187.
CAS Number
– 1415558-82-5
Molecular Weight
– 464.32
SMILES
– O=C1CC(N2N=CC(C3=CC(O[C@H](C)C4=C(Cl)C(F)=CC=C4Cl)=C(N)N=C3)=C2)CCN1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Anaplastic lymphoma kinase (ALK)
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
