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2′-F-Bz-dC Phosphoramidite
$75 – $120
Products Details
Product Description
– 2′-F-Bz-dC Phosphoramidite can be used in the synthesis of oligoribonucleotide (such as DNA and RNA). 2′-F-Bz-dC Phosphoramidite also used for synthesis antiviral agent to inhibit the replication of virus. 2′-F-Bz-dC Phosphoramidite contains a phosphorothioate backbone, to synthesise antisense oligonucleotide analogs to induce apoptosis in cancer cells[1][2][3].
Web ID
– HY-138577
Storage Temperature
– 4°C (Powder, protect from light, stored under nitrogen)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C46H51FN5O8P
References
– [1]Reif B, et, al. Structural Comparison of Oligoribonucleotides and Their 2′-Deoxy-2′-fluoro Analogs by heteronuclear NMR spectroscopy. Helvetica Chimica Acta. 1997 Jou; 80(6): 1952-1971.|[2]Zhang Hongyan, et al. Combined drug for treating hepatitis B and its application in preparing drugs for preventing and/or treating HBV (hepatitis B virus)-induced symptom or diseases. China, CN112007040 A. 2020-12-01. |[3]Monia Brett P, et al. Antisense oligonucleotides for modulation of telomerase catalytic subunit gene expression and treatment of cancer. World Intellectual Property Organization, WO2001088198 A1. 2001-11-22.
CAS Number
– 161442-19-9
Molecular Weight
– 851.90
Compound Purity
– 99.88
SMILES
– COC1=CC=C(C(C2=CC=C(OC)C=C2)(OC[C@@H]3[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](F)[C@H](N4C=CC(NC(C5=CC=CC=C5)=O)=NC4=O)O3)C6=CC=CC=C6)C=C1
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– DNA/RNA Synthesis;Nucleoside Antimetabolite/Analog
Pathway
– Cell Cycle/DNA Damage
Product type
– Oligonucleotides
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
