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Products Details
Product Description
– 2′-Thioadenosine (PD157432) is a selective and irreversible inhibitor of ErbB-1 and ErbB-2, with an IC50 of 45 µM for ErbB-2. 2′-Thioadenosine covalently inactivates ErbB-1 via modification of a cysteine residue at the active site[1].
Web ID
– HY-137028
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C10H13N5O3S
References
– [1]Singh J, et, al. Structure-based design of a potent, selective, and irreversible inhibitor of the catalytic domain of the erbB receptor subfamily of protein tyrosine kinases. J Med Chem. 1997 Mar 28;40(7):1130-5.
CAS Number
– 136904-69-3
Molecular Weight
– 283.31
SMILES
– NC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3S)C2=NC=N1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– EGFR
Isoform
– EGFR/ErbB1/HER1;ErbB2/HER2
Pathway
– JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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