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Product Description
– 2′-Deoxy-β-L-uridine is a nucledside analogue and a specific substrate for the viral enzyme, shows no stereospecificity against herpes simplex 1 (HSV1) thymidine kinase (TK). 2′-Deoxy-β-L-uridine exerts antiviral activity via the interation of 5′-triphosphates with the viral DNA polymerase[1][2].
Web ID
– HY-W353804
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C9H12N2O5
References
– [1]Spadari S, et al. L-thymidine is phosphorylated by herpes simplex virus type 1 thymidine kinase and inhibits viral growth. J Med Chem. 1992 Oct 30;35(22):4214-20. |[2]Lin TS, et al. Design and synthesis of 2′,3′-dideoxy-2′,3′-didehydro-beta-L-cytidine (beta-L-d4C) and 2′,3′-dideoxy 2′,3′-didehydro-beta-L-5-fluorocytidine (beta-L-Fd4C), two exceptionally potent inhibitors of human hepatitis B virus (HBV) and potent inhibitors of human immunodeficiency virus (HIV) in vitro. J Med Chem. 1996 Apr 26;39(9):1757-9.
CAS Number
– 31501-19-6
Molecular Weight
– 228.20
SMILES
– O=C(NC(C=C1)=O)N1[C@@H]2C[C@@H](O)[C@H](CO)O2
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Nucleoside Antimetabolite/Analog
Pathway
– Cell Cycle/DNA Damage
Product type
– Oligonucleotides
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