Download Files:
Products Details
Product Description
– 14-3-3σ/ERα stabilizer-1 (Compound 181) is a covalent 14-3-3σ/ERα stabilizer. 14-3-3σ/ERα stabilizer-1 can be used for research of molecular glues[1].
Web ID
– HY-156125
Shipping
– Room temperature
Molecular Formula
– C25H35Cl2N3O3
References
– [1]Konstantinidou M, et al. Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein-Protein Interaction from Nonselective Fragments. J Am Chem Soc. 2023 Sep 20;145(37):20328-20343.
Molecular Weight
– 496.47
SMILES
– CC1CC(C(N2CCC3(CC2)CCN(CC3)C(CCl)=O)=O)(CC(O1)C)NC4=CC=C(C=C4)Cl
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– 10 mM in DMSO
Target
– Estrogen Receptor/ERR
Pathway
– Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
