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Products Details
Product Description
– 12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, is a potent Ca2+-activated K+ (BK) channel opener. 12,14-Dichlorodehydroabietic acid blocks GABA-dependent chloride entry in mammalian brain and operates as a non-competitive GABAA antagonist. 12,14-Dichlorodehydroabietic acid increases cytosolic free Ca2+ and stimulates transmitter release[1][2].
Web ID
– HY-133596
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C20H26Cl2O2
References
– [1]R A Nicholson, et al. Inhibition of GABA-gated chloride channels by 12,14-dichlorodehydroabietic acid in mammalian brain. Br J Pharmacol. 1999 Mar;126(5):1123-32.|[2]Kazuho Sakamoto, et al. Molecular mechanisms for large conductance Ca2+-activated K+ channel activation by a novel opener, 12,14-dichlorodehydroabietic acid. J Pharmacol Exp Ther. 2006 Jan;316(1):144-53.
CAS Number
– 65281-77-8
Molecular Weight
– 369.33
SMILES
– O=C([C@]1(C)CCC[C@]2(C)C3=C(CC[C@@]12[H])C(Cl)=C(C(C)C)C(Cl)=C3)O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– GABA Receptor;Potassium Channel
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
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