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Product Description
– 11-Ketodihydrotestosterone-d3 is the deuterium labeled 11-Ketodihydrotestosterone. 11-Ketodihydrotestosterone (11-KDHT; 5α-Dihydro-11-keto testosterone) is an endogenous steroid and a metabolite of 11β-Hydroxyandrostenedione. 11-Ketodihydrotestosterone is an active androgen and is also a potent androgen receptor (AR) agonist with a Ki of 20.4 nM and an EC50 of 1.35 nM for human AR. 11-Ketodihydrotestosterone drives gene regulation, protein expression and cell growth in androgen-dependent prostate cancer cells[1][2].
Web ID
– HY-135794S
Shipping
– Room temperature
Molecular Formula
– C19H25D3O3
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Pretorius E, et al. 1-Ketotestosterone and 11-Ketodihydrotestosterone in Castration Resistant Prostate Cancer: Potent Androgens Which Can No Longer Be Ignored. PLoS One. 2016 Jul 21;11(7):e0159867.|[3]du Toit T, et al. Profiling adrenal 11β-hydroxyandrostenedione metabolites in prostate cancer cells, tissue and plasma: UPC2-MS/MS quantification of 11β-hydroxytestosterone, 11keto-testosterone and 11keto-dihydrotestosterone. J Steroid Biochem Mol Biol. 2017 Feb;166:54-67.
CAS Number
– 2479914-02-6
Molecular Weight
– 307.44
SMILES
– O[C@]1(C([2H])(C[C@@]([H])([C@@]2(CC[C@]3(CC(CC[C@@]3([C@]24[H])C)=O)[H])[H])[C@@]1(CC4=O)C)[2H])[2H]
Clinical Information
– No Development Reported
Research Area
– Endocrinology
Solubility
– 10 mM in DMSO
Target
– Androgen Receptor;Isotope-Labeled Compounds
Pathway
– Others;Vitamin D Related/Nuclear Receptor
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
